Oral medication is typically the first thing we suggest to our patients as they present a quick and easy solution to their problem. The only difference between oral and sublingual tablets for erectile dysfunction is that the latter work faster because in this case the medication dissolves in your mouth and absorbs straight into the bloodstream through the tongue tissue. Peak blood level of such medications are achieved in between 15-45 minutes. Whereas, oral drugs may take twice as long to have any effect.How does sublingual erectile dysfunction medication work? It enhances the effects of nitric oxide – the chemical that your body naturally produces to relax penile muscles and increase the blood flow to cause an erection. The pills only work in response to sexual stimulation. Depending on the dosage, tablets can be divided into ones that can be taken daily and ones that should be taken right before you plan to have intercourse.